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This incredibly diverse South American country has so much to offer, it’s impossible to choose just one region within it. Adventure-seekers and nature enthusiasts should explore the Amazon aboard a river cruise by boutique outfitter Delfin Amazon Cruises. The Belmond Andean Explorer is the luxe new way to experience Cuzco and the highlands by train. And Lima is worth a trip for its colonial architecture, stunning Pacific coastline, and hot restaurant scene.